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2

抑制剂 & 化合物

2

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T36066	NADP+ (sodium salt hydrate)
	NADP+ is the oxidized form of the electron donor nicotinamide adenine dinucleotide phosphate . It serves as a cofactor in various biological reactions. In addition, the balance between these reduced and oxidized forms plays key roles in diverse cellular functions, including cell survival, the maintenance of redox status, and intracellular signaling. For example, binding of NADP+ to β-subunits of Kv channels activates ion transport, whereas NADPH stabilizes channel inactivation. NADP+ is biosynth...
T83866	LCC-12 formate
	LCC-12是一种铜(II)螯合剂，为二甲双胍的衍生物。作为单体，它能结合铜(II)并在20 µM的浓度下减少氢过氧化物依赖的NADH向NAD+的氧化。在10 µM的浓度下，LCC-12降低一次性人类细胞因子激活的单核衍生的巨噬细胞(MDMs)中IL-1β、IL-2、IL-6、IL-8和TNF-α的细胞因子水平，以及JAK2、STAT2和IL-1受体相关激酶4(IRAK4)的水平。此外，同样浓度的LCC-12减少了细胞因子激活的MDMs中CD80+和CD86+的数量。每日0.3 mg/kg的剂量可提高LPS或盲肠结扎穿孔模型小鼠的存活率。

化合物

NADP+ (sodium salt hydrate)

Cat.No: T36066

Cat.No: T83866

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPJ-00462	NADK Protein, Human, Recombinant (His) Poly(P)/ATP NAD Kinase,NADK,N...	Human	E. coli
	NAD Kinase (NADK) is an enzyme that belongs to the NAD Kinase family. It is a widely expressed enzyme, but it is not detected in skeletal muscle. NADK converts Nicotinamide Adenine Dinucleotide (NAD+) into NADP+, through phosphorylating the NAD+ coenzyme. NADP+ is an essential coenzyme in metabolism and provides reducing power to biosynthetic processes such as fatty acid biosynthesis. The structure of the NADK from the archaean Archaeoglobus fulgidus has been determined.
TMPJ-00955	MDH1 Protein, Human, Recombinant (His) Cytosolic Malate Dehydrogenase,MDH1,MDHA,Diiodophenylpyruvat...	Human	E. coli
	Malate Dehydrogenase, Cytoplasmic (MDH1) is an enzyme which belongs to the MDH Type 2 sub-family of LDH/MDH superfamily. MDH1 is involved in the Citric Acid Cycle that catalyzes the conversion of Malate into Oxaloacetate (using NAD+) and vice versa. MDH1 should not be confused with Malic Enzyme, which catalyzes the conversion of Malate to Pyruvate, producing NADPH. MDH1 also participates in Gluconeogenesis, the synthesis of Glucose from smaller molecules. Pyruvate in the mitochondria is acted up...

重组蛋白

NADK Protein, Human, Recombinant (His)

Cat.No: TMPJ-00462

Species: Human

Expression System: E. coli

MDH1 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00955

Species: Human

Expression System: E. coli

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